الفهرس | Only 14 pages are availabe for public view |
Abstract Aim of the work The aim of the work is to evaluate the histopathologic and sonographic findings of the diabetic liver and its correlation with liver function tests. Results of this study showed 1- Positive correlation between poorly controlled diabetic patients (high level of fasting, post-prandial blood sugar and glycosylated haemoglobin) and liver enlargement, fatty liver in both IDDM and NIDDM. 2- Hepatomegaly and fatty infiltration were found to be common in IDDM than in NIDDM. 3- No relation between glycaemic control of diabetic patients and total serum bilirubin, total protein and liver enzymes in both IDDM and NIDDM. 4- Positive correlation between glycaemic control of diabetic patients (poorly controlled) and low level of albumin in both IDDM and NIDDM. 5- Positive correlation between duration of diabetes mellitus and liver enlargement, fatty liver in both IDDM and NIDDM. 6- No relation between duration of diabetes mellitus and total serum bilirubin, total protein and liver enzymes in both IDDM and NIDDM. 7- Positive relation between duration of diabetes mellitus and low level of albumin in both IDDM and NIDDM. The conclusion of histopathologic examination of liver biopsies: 1- Increasing severity of fatty metamorphosis from well controlled diabetes to poorly controlled diabetes was found. 2- Glycogen nuclei and PAS-positive blood vessels in portal tracts were significantly more prevalent in poorly controlled diabetes than in well controlled diabetes. 3- Finally, the distribution of significant liver histopathology in diabetic patient correlates in severity with the degree of impaired glycogen status. |