الفهرس 
Introduction and Aim of the workOnly 14 pages are availabe for public view
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Abstract
The aims of this work are:
1- To compare the efficacy of vaginal administration of bromocriptine versus oral use.
2- To evaluate the side effects reported during the study period in both groups.
3- To report the accessibility of the new route of administration by the patient.
Conclusions:
The incidence of side effects was less in vaginal group in comparison with that of the oral group. In case of nausea and vomiting the difference was statistically significant. While in case of headache, that difference was very highly significant.
Menstruation became normal in 88.8% of the women in both groups after three months of treatment.
Galactorrhea disappeared in both groups, where it disappeared in 12 (66.7%) in the oral group, and in 14 (77.8%) in the vaginal group after the third month of treatment. The difference was statistically insignificant.
Prolactin level was reduced in both groups, where it reduced from a mean of 78 +(-) 19 to 16 +(-) 4 in the oral group, while it reduced from a mean of 81 +(-) 22 to 15 +(-) 4 in the vaginal group after the third month of treatment, the difference in reduction in both groups was statistically insignificant.
Two cases of the vaginal group (10%) got pregnant after the third month of treatment, while none got pregnant in the oral group.
In conclusion, the vaginal route of bromocriptine administration was demonstrated to be a safe and effective method of therapy for hyperprolactinemia. Foe women with gastro-intestinal side effects it may the only alternative.