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Abstract The aim of this study is to determine the important gastrointestinal endoscopic and histopathologic findings in patients with portal hypertension secondary to liver cirrhosis. Also, to find out whether these findings are correlated with clinical, laboratory, sonographic and splenic manometric parameters. The impact of sclerotherapy on clinical, laboratory, sonographic, splenic manometry, endoscopic and histopathologic findings will be addressed as well. This study concluded that there was increased incidence of and histopathologic gastrointestinal vasculopathy with increased portal pressure. Also, sclerotherapy has an adverse effect on GIT by increasing the portal pressure and the endoscopic changes throughout the entire gastrointestinal tract. Whatever may be the trend to control or reduce portal pressure, there should be much attention with further prospective studies towards the integrity of the liver as an organ which may suffer from reduced portal blood flow which may lead to deterioration of liver function, and increased incidence of hepatic cell damage as a result of hepatic ischemia. |