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العنوان
Antioxidants in some Neonatal Illnesses /
الناشر
Salwa Sleem Shohdy,
المؤلف
Shohdy, Salwa Sleem
هيئة الاعداد
باحث / سلوى سليم شهدى
مشرف / سميرة زين سيد
مشرف / علي رجاء عبد العال
مشرف / منال أحمد مندور
الموضوع
Pediatrics Antioxidants Antioxidants in some Neonatal Illnesses
تاريخ النشر
1997 .
عدد الصفحات
140 p.
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
طب الأطفال ، الفترة المحيطة بالولادة وصحة الطفل
تاريخ الإجازة
1/1/1997
مكان الإجازة
جامعة المنيا - كلية الطب - طب الأطفال
الفهرس
Only 14 pages are availabe for public view

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from 162

Abstract

Aim of the work
To measure the serum antioxidants enzymes (SOD, glutathione peroxidase) activity, ceruloplasmin activity, vitamin E, bilirubin and lipid peroxidation levels in preterm infants with neonatal asphyxia and physiological jaundice. Also we measured them in full term infants with neonatal asphyxia, physiological jaundice and IDMs. We compared their levels to those preterm and full term healthy infants.
Conclusion
1- From our study we concluded that antioxidants clearly have an important role in the defense mechanism against free radical induced organs injury.
2- A preterm infant is more susceptible to neonatal oxygen radical disease than full term infant, because they have low antioxidants activity against excess production of oxygen.
3- Decrease in the antioxidants activity in neonatal asphyxia and also excess free radical production during reperfusion after ischemia are the main cause of what is called hypoxic-ischemic brain injury.
4- In infants of diabetic mothers excess oxygen radicals and low antioxidants activity are the most common causes for congenital malformation.
5- Hyper bilirubinemia which occur on the first postnatal days may not be harmful to the baby because bilirubin acts as physiological antioxidants in vivo.
6- Augmentation of the antioxidant defense mechanism is very important to protect the neonates against the harmful effect of oxygen free radical disease of neonates.