الفهرس | Only 14 pages are availabe for public view |
Abstract Aim of the work The aim of this essay is to highlight the recent advances in the pathophysiology of wound healing and the possibility of applying the new concepts to improve healing and to minimize scarring and wound complications. Also, to present the recent trends in wound care including the management of chronic none healing wounds. Conclusions The use of hyperbaric oxygenation either as primary treatment for non surgical candidates or as an adjunct to surgical; treatment needs further investigations though the recent studies are impressive. Today, electrical stimulation devices are available to facilitate healing. The use of electrical electrical to induce bone healing in delayed union and non union a fracture is now widely accepted as an alternative or supplement to the use of bone grafts. Effects produced by continuous or pulsed direct current appear to have the greatest reliability on skin wound healing. On going research will soon unravel the complexities of electrical therapy and clinicians can anticipate another alternative to assist them in healing of complicated and none healing wound. Single growth factors in therapy of insufficiently healing wounds gives good results. A future concept may be a growth factor cocktail, consisting of various factors at certain concentrations. Experimental trials must also rule out possible risks such as oncogenic effects of growth factors. To reduce the risk of scar stretching, scars whenever possible should be placed in lines of relaxed skin tension. Prolonged dermal support with subcuticular suture may also reduce the incidence of scar stretching. Experimental injection of neutralizing antibodies to transforming Growth factor- β1 and β2 (TGF- β1& TGF- β2) in healing wounds resulted in virtually scarless healing. Radical pharmacological control of scar formation in the human appears to be a realistic possibility. |