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Abstract
Abstract
This study aimed at studying the effect of fish oil and cod liver oil supplementation on asthmatic children. The study included forty children with acute attacks of bronchial asthma, their age ranged between 6 to 12 years old and they received their standard medical treatment. All children with inclusion criteria were enrolled in this study for 16 weeks and they were divided into 4 equals groups ( 10 for each group ) as follow : 1-Control group 2-Fish oil group 3-Cod liver oil group 4-Mixed group . Data about socioeconomic status, health status, food habits and consumption pattern, food intake, and anthropometric measurements were obtained, also laboratory investigations was carried out on fresh blood serum for determination of different biochemical parameters. Regarding clinical severity of asthma, in fish oil group the moderate cases (40%) before dietary intervention becomes (20%), and sever cases diminished from 20% before dietary intervention to become 10% after dietary intervention. Among cod liver oil groups the moderate and severe cases were 50% and 20% before dietary intervention, but after dietary intervention becomes 40% and 10% respectively. Only, in mixture and control groups the moderate cases improved from 50% before dietary intervention to 40% after dietary intervention.Regarding IgE, the results showed that before dietary intervention there were no significant differences between values of different groups. Also, the same trends were observed after dietary intervention. However, the dietary intervention resulted in significant decrement of IgE among each of fish oil group that decreased from; 314.9±52.5 to 264.0±42.6 and P<0.001; cod liver oil group that decreased from 328.7±93.8 to 283.7±86.3 and P<0.05; and mixture group that decreased from 318.0±66.4 to 270.8±70.9 and p<0.01. The percentage of decrement of IgE level after dietary intervention were 16%, 13.6%, and 15.3% respectively among fish oil, cod liver oil, and mixture groups.Our dietary intervention , with fish oil , mixture, and cod liver oil resulted in significant decrement of IgE level by 16% , 14.8%, and 13.7%, respectively . These favorable effects could be attributed to that omega-3 containing oils reduces the inflammatory mediators like leukotreines and prostaglandin’s, and hence reduced the IgE level and overall the immune response . The results of this study proved that fish oils had a favorable affect on asthma and decreased IgE values, that reduce the inflammation and relief the symptoms accompanying asthma.