Author: Amr, Abd El-Hamid Gaber Abd El-Hamid./ Title: Effect of simvastatin and losartan on hepatic fibrosis induced by bile duct ligation in rats \

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العنوان

Effect of simvastatin and losartan on hepatic fibrosis induced by bile duct ligation in rats \

المؤلف

Amr, Abd El-Hamid Gaber Abd El-Hamid.

هيئة الاعداد

باحث / Abd El-Hamid Gaber Abd El- Hamid Amr

مشرف / Adel Hussein Omar.

مناقش / Abd El-Aziz Abas Talab.

مناقش / Magda Ahmed Mansour.

الموضوع

Gallbladder- Diseases. Hepatic Fibrosis.

تاريخ النشر

2008.

عدد الصفحات

110 p. :

اللغة

الإنجليزية

الدرجة

ماجستير

التخصص

الطب

تاريخ الإجازة

1/1/2008

مكان الإجازة

جامعة المنوفية - كلية الطب - Pharmacology

الفهرس

Only 14 pages are availabe for public view

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Abstract

Hepatic fibrosis is a complex process characterized by excessive accumulation of extracellular matrix proteins in which hepatic stellate cells (Ito cells) play a key role.The aim of this study is to determine the effects of simvastatin (HMG-CO A reductase enzyme inhibitor) and losartan(angiotesin II receptor blocker ) on hepatic fibrosis induced in rats by bile duct ligation.
١-The use of simvastatin alone in liver fibrosis worsen the condition.
٢-The use of losartan alone in liver fibrosis showed good improvement in the hepatic fibrosis .
٣-The use of simvastatin plus losartan in liver fibrosis showed very good improvement.