الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
The relation in chemical structure between 1,2-diphenyl— ethylamine and certain structural entities in morphine, bulbo— eapnine, and papaverine,prompted us to synthesise and to investigate the biological activity ot some derivatives of 1-(4—biphenylyl)-2—phenylethylamine. The synthetic route was commenced by the preparation of benzyl—4—biphenylyl ketone from “phenylacetyl chloride” and “biphenyl.” by applying the Friedel and Graftts conditions The key intermediate; l—(4—biphenylyjj- 2-phenylethylamine; was obtained either by the reduction of benzyl—4—biphenylyl ketoxime or from the ketone itself through modified Leuckart—Wallach reaction. The N—alkyl and the N,N..dialkyl—l—(4—biphenylyJ.)—2—phenylethylamines were prepared from the corresponding N—acyl and N—lkyl—N—acyl—analogues respectively, by reduction with lithium aluminium hydride in absolute ether. The N,L•imethyl and N-alkyl—N—met’:yl derivatives were also obtained through Clarke—Eschweiler reaction. In addition, the N— benzoyl and N— benz.yl—N—methyl—l—(4— biphenylyl) -2-phenyl— ethylamines ‘here preparede Microanalytical data, for the prepared new compounds, as ‘well as IR and &R spQctral studies on some representative examples were recorded.
A brief survey on some pharmacological aspects vf morphine and substitutes, bulbocapnine, papaverine, and aralkyl— amines were included. Moreover, some currently accepted mechanisms for the reactions utiliseci in the preparation of the new compounds, were discussed.