الفهرس | Only 14 pages are availabe for public view |
Abstract AIM OF THE WORK This study aimed to: 1. Evaluate the relationship between non-alcoholic fatty liver disease (NAFLD) and atherosclerotic cardiovascular diseases (CVD). 2. Evaluate the role of inflammation in the pathogenesis of both non-alcoholic fatty liver disease (NAFLD) and atherosclerotic cardiovascular diseases (CVD). According to these results we concluded that : NAFLD was associated with more advanced atherosclerosis, greater carotid IMT and higher prevalence of carotid plaques independent of Met $. presence of NAFLD may be an early indicator of active pre-morbid cardiovascular state and uncover undulant atherosclerotic cardiovascular disease. Non-alcoholic fatty liver diseases cauld be an important tool to improve cardiovascular risk stratification independent of Met $ and conventional cardiovascular risk facores. Higher levels of hs-CRP are associated with more advanced coronary astherosclerosis, greater Carotid IMT, higher prevalence of carotid plaques and indirectly reflects higher vulnerability of plaques. Determination of hs-CRP levels in patients with high cardiovascular risk may detect more vulnerable patients and improve conventional cardiovascular risk stratification strategies. Also, for further researching, we recommended that: Other mechanisms linking NAFLD with accelerated atherosclerosis: such as reactive oxygen species, hypoadiponectinemia, and abnormal Apolipoproteineamia. Anti-inflammatory therapies, hs-CRP lowering drugs, including specific cytokine inhibitors are promising as they can improve outcomes of acute coronary syndromes. The inflammatory hypothesis of atheroclerosis changing our attitude toward prevention and treatment of acute ischemia for example: 1 Plaque stabilization gain more importance. 2 CABG gain more confidence. 3 Revascularization procedures gain less reliance. |