الفهرس 
General IntroductionOnly 14 pages are availabe for public view
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Abstract
The thesis falls into five main parts
Part I:
Include the general introduction about calcium channel blocker drugs, especially the studied drugs, their classification, pharmacological effect, metabolism, their physical and chemical properties.
Part II
This part is concerned with the development of simple, rapid, accurate and sensitive spectrophotometric method for determination of the three drugs through ion pair formation with some dyes such as: eriochromecyanine and the three drugs in presence citric acid, sulfochlorophenol-S and the three drugs in presence of sulfuric acid, bromopyrogallol red and the three drugs in presence of sulfuric acid and pyrocatechol violet and two drugs in presence of sulfuric acid producing a highly colored ion pair complex extractable in chloroform. Then the absorption intensities of the organic phases were measured at lmax = 462, 600, 440 and 442 nm respectively, reaction conditions were carefully studied and optimized. Beer’s law was obeyed in the range 2.5 − 80 µg ml-1.
Part III:
This part includes calculation of the formation constants of the formed ion pair complexes between each studied drug and each one of the used dyes namely; SCPS, ECC, BPR and PCV.
Part IV:
This part is concerned with development of direct, rapid, accurate, sensitive and easy method for determination of amlodipine besylate by square–wave adsorptive cathodic stripping voltammetric technique. While the adsorption behavior of the amlodipine besylate onto a HMDE which explored by square-wave and cyclic voltammetry. The drug was accumulated at HMDE and a well-defined peak was obtained at –1.73 V versus Ag/AgCl (saturated KCl) in phosphate buffer pH 7.
Part V:
This part includes the summary and conclusions.
The thesis contains 40 tables, 37 figures and 262 references.