الفهرس 
acknowledgmentOnly 14 pages are availabe for public view
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Abstract
The resistance to penicillin in strains of Staphylococcus reus was found to be due to production of B—lactamase (peni— cillinase) enzyme. In recent years several works have reported a increase in the percentage of community strains that produ— cepenicillinase, most probably due to the extensive use of
—
nicillins. bince such an increase will affect the choice of
rb0tC it was considered of importance to study in the pre— ;t work; the occurrence of B—lactamase enzyme in staphylococci trains and to over come its interfering effect with the chemo— erapeutic treatment of resistant strains.
This study started by isolation of 207 staphylococci strains roi different clinical samples. 95% of these strains were peni—
• ‘ilinase—producers. The level of resistance of these strains was ryhigh to 12 different commonly used antibiotics, only diclo— illin and cephalothin —being B—lactamase inhibitors— were eff— tive. It was noted that most of the isolated strains exhibited
.ple antibiotic resistance.
In order to study the effect of some antibiotics inhibiting
11 functions on the synthesis of B—lactamase enzyme in some the isolated staphylococcal strains, certain factors connected the location, production and isolation of this enzyme were
tigated. penicillinase enzyme was mainly bounded to the cells ‘the all tested strains and to obtain enzyme preparations the ce:
re disrupted in an ultrasonic disintigrator.