الفهرس 
Introduction and Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
Aim of the work
The aim of our study is to address the genetic familial factor in hypertension through the evaluation of vasodilator capacity and baroreceptors sensitivity in normotensive offspring of hypertensive patients.
Conclusion
We conclude that there is an obvious endothelial dysfunction, paroreflex impairment and altered sympathovagal balance in offspring of hypertensive parents, preceding their development of hypertension. Those traits are inherited to them from their hypertensive parents, and being more if they are inherited from both parents.
This endothelial dysfunction may be due to a genetic defect in nitric oxide (NO) synthesis pathway either in production of NO synthase enzyme. NOS isoforms, co-factors for NOS induction and inhibition and/ or L- arginine which is the NO substrate or its analogues.
Also, the autonomic disturbance is due to a genetic defect, which makes them more susceptible to environmental stresses resulting in a high sympathetic tone in those subjects.
Finally, the inherited impaired baroreceptors sensitivity and autonomic dysfunction together with the endothelial dysfunction and defective nitric oxide may represent mechanisms through which subjects with familial predisposition for hypertension may develop hypertension later on in their life.