الفهرس 
Introduction and Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
Aim of the work
1- To evaluate the clinical implication of serum levels of IL-18 among patients with ACS in comparison with other markers of chronic inflammation.
2- To assess the relation of IL-18 serum levels with various conventional cardiovascular risk factors.
3- To study the possible role of IL-18 in plaque instability and myocardial dysfunction.
Conclusion
Serum levels of IL-18 were higher in ACS, UA and AMI groups versus healthy volunteers. The proinflammatory role of IL-18 in the initiation and progression of atherosclerosis was proved in the present study by the presence of positive significant correlation between serum levels of IL-18 and some markers of chronic inflammation as fibrinogen, and NO. Also, the percentage of CRP positive patients was higher in ACS, UA and AMI groups than coronary and non coronary control groups.
Increased IL-18 was correlated with family history of premature CAD, cholesterol, triglycerides, LDL-C and OX-LDL.
IL-18 serum levels may play a role in plaque instability as determined by its higher serum levels in ACS, UA and AMI groups versus SA group.
Increased serum levels of IL-18 may lead to increased incidence of left ventricular systolic dysfunction among patients with ACS.