الفهرس 
INTRODUCTION AND AIM OF THE WORKOnly 14 pages are availabe for public view
 |  | from | 136 |  |  |
| | | from | 136 | | |
Abstract
Aim of the work
The aim of this study is to explore the clinical significance of serum VEGF in patients with chronic liver diseases.
The main results of this study were:
1- There was a statistically higher levels of circulating VEGF in patients with chronic liver diseases (chronic hepatitis, liver cirrhosis and HCC) than that in normal controls.
2- There was a statistically significance higher levels of circulating VEGF in patients with HCC than those in chronic hepatitis and liver cirrhosis.
3- There was a statistically significant negative correlation between VEGF levels and platelet count in patients with chronic liver diseases.
4- There was no significant correlation between VEGF and the grade of oesophaGEAL varices either in liver cirrhosis or HCC patients.
5- There was a statistically significant negative correlation between VEGF and upper GIT bleeding or spider naevi (vascular skin changes) in patients with chronic liver diseases.
6- There was a statistically significance correlation between VEGF and degree of hepatic dysfunction (child-Pugh classification and liver enzymes).
In conclusion, there was a strong correlation between VEGF level and chronic liver disease, especially highly correlated with HCC. Also. There is a close relation between VEGF and hepatic dysfunction as well as platelet count. More studies are needed to clarify the regulatory mechanisms of VEGF in liver diseases.