الفهرس 
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Abstract
The present study included L 00 tuberculous patients who were admitted to Chest Department Diseases in El-Minia University Hospital during the period from March 1995 to February 1996. Their ages ranged from to - 59 years with a mean of (35.62) . The percentage of males to females was 45 - 55 % .
Patients were classified into two groups : -
Group A : included 50 patients with newly discovered tuberculosis . (47 with pulmonary and 3 with extrapulmonary tuberclosis ).
Group B: included 50 patients under anti-tubrculosis treatment, before the study (48 with pulmonary and 2 with extrapulmonary . tuberculosis).
All the patients were further classified into five groups according to tlte regimen of drugs used :
Group I: Included 61 patients and their drug regimen consisted of INn, RMP and ETB .
Group IL: Included 9 patients and their drug regimen consisted of strept., RMP and INH.
Group III:Included 16 patients their drug regimen consisted of strept., INH and ETB .
Group IV: Included 13 patients and their drug regimen consisted ofRMP, INH and Z .
G roup V: Included one patient and his drug regemin consisted of strept + INH + ETB + Z.
During this work full clinical, radiological and laboratory assessment were done for all patients, at the start of the study and repeatedly during the period of follow up (9 months). And also complete liver function tests were done to all patients before iniating any chemotherapy, and repeated every week in the first month, every two weeks in the second 1110nth and every four weeks thereafter up to 9 month.
ELISA test were done to patients whom developed change in their liver function
Tile results of tile study revealed : -
Thirty - one patients developed hepatitis, all of them were jatmdiced,
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16 developed nause~, and vomiting and 6 developed prudtis’.Hwenty - two
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patients (71 %) /oS hepatitis oecuned in the first three months of
antituberculous therapy and the remaining in the latter months. Serological markers of acute hepatitis was confinned in 26 (84%) out of 31 patients with hepatic reaction. Hepatitis C virus (HCV) represents. 45%, hepatitis B Virus (HBV) 29% and 3 patients (10%) with hepatic reaction were seropositive to both HCY and HBV. Only 5(16%) out of 31 patients proved to have drug °induced hepatitis during their antituberculosis management.
The present study also showed that increasing age was associated with a signi1icant increase in the incidence of hepatitis. Males has a higher incidence of hepatic reactions than females and fanners are more liable to develop viral hepatitis.