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Abstract Aim of the work To investigate the possible role of IL-10 and IL-12 in preterm newborns with respiratory distress syndrome (RDS) and their relation to the severity of RDS. Conclusion We conclude from these findings that of IL-10 and IL-12 can be used as indicators for the risk of developing RDS in the preterm infants. Both of IL-10 and IL-12 have good prognostic values for diagnosis and assessing severity of respiratory distress syndrome as assessed by duration of distress and also they have better prognostic values than gestational age and birth weight for detecting the outcome of cases. Of IL-10 and IL-12 levels in cord blood most probably indicate functional immaturity of the preterm. Recommendations 1- Assessment of IL-10 and IL-12 in cord blood of preterm infants for the prediction of the development of RDS and its severity and for prediction of the outcome. 2- Further studies are needed to clarify the pathogenesis of the increase in of IL-10 and the decrease of IL-12 in preterm with RDS. |