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Abstract
Colibacillosis considered one of the most common and serious disease that hindered the
development of the rabbit breeding and industries, so the aim of the study to clarify the
effect of colibacillosis on both clinical pathological parameters. Our work devided into
field studying on naturally infected rabbits at weanling age with colibacillosis which
revealed Escherichia coli was isolated In bacteriological examination, also to
experimental infection by E. coli 0 103 isolated from naturally infected cases. The
experimental infection was done as followed (group I of twenty rabbits at concentration
6x108CFU, group II of twenty rabbits at concentration 3xl08CFU and group III ten
rabbits used as control). Hematological, biochemical and histopathological examination
revealed great affection resulted in tissue damage (liver, kidneys and intestine) that
confirmed by increased the level of liver enzymes, bilirubin (direct and indirect) urea,
creatinine, whereas glucose and sodium decreased but potassium did not change also
colibacillosis led to anaemia and leukocytosis.