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Abstract Colibacillosis considered one of the most common and serious disease that hindered the development of the rabbit breeding and industries, so the aim of the study to clarify the effect of colibacillosis on both clinical pathological parameters. Our work devided into field studying on naturally infected rabbits at weanling age with colibacillosis which revealed Escherichia coli was isolated In bacteriological examination, also to experimental infection by E. coli 0 103 isolated from naturally infected cases. The experimental infection was done as followed (group I of twenty rabbits at concentration 6x108CFU, group II of twenty rabbits at concentration 3xl08CFU and group III ten rabbits used as control). Hematological, biochemical and histopathological examination revealed great affection resulted in tissue damage (liver, kidneys and intestine) that confirmed by increased the level of liver enzymes, bilirubin (direct and indirect) urea, creatinine, whereas glucose and sodium decreased but potassium did not change also colibacillosis led to anaemia and leukocytosis. |