الفهرس 
Tuberculosis ; importance & pathogenesisOnly 14 pages are availabe for public view
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Abstract
Till now tuberculosis is onsider d one of the most important communicable
eli e, s in the world, a its annual number of new ca es ex d d 8.7 million
ases by the year 2000, with number of deaths ranging from 1,5-1.9 million
deaths ...W
Pathologically pulmonary tuberculosis is onsidered one of the granulomatous
disea ,it gJi’anuloma.· form d of tiny tubercl consi t mainl t alv olar
rnacrophages , pith lioid cells, Langhans giant cells and lymphocytes •..2 •
1tens angiogenesis (new blood vessel formation) has n found occurring in
a tive pulmonary tuber ulou 1 sions ...3
). Macropha es have been identified to have th potentia] to produce va ular
endothelial growth factor (VEGF), ..@ .which is kn wn to be i1SS0 ie ted with
angiogen sis in Crohn’s di ase (on of th granulomatous di eases) ...@,.od in
malignant tumours ...@
V. scular endothelial growth factor (VEGF) is an interesting multifun tional
t kine th t act as an indu er f angiogenesis and lymphangiog n is, becau e
it i a highly pecific nut g :1 f r ndcthelial cell .Signal transduction inv lves
binding to tyrosine kinase receptors and r suits in angiogenesis bj both dir t
and indirect me hanisms. On on hand, VEGF stimular the endothelial cell
lining nearby microvcssels to proliferate, to migrate, and to alter th 11’ p. ttern of
gene expression. On the other hand, VEGF r nd 1’S th e am microva ’ul. r
endothelial cells hyperperm abl so that they spill plasma proteins in-to th
xtrava Ie r spa e, 1 ding to lotting f trawl ted fibrin g n with
depo ilion of a fibrin geL, xtravas rular mrin s IV as a provisional matrix that
favor and suppor th ingrowth. of new blood yes I and ther me nchymal
lls that genel’< te matur ,v culs rized troma. Th arne prin iple apply in
tumors, in several examples of non-n oplastic pathology, and in physiological
processes that involveangiogenesis and new stroma generation ....(Z ID
It is sugg sted that alv alar macrophag s in pulmonary tuberculosis may release
vascular ndothelial growth factor which is contributing in the pathogenesis of
tube ulosi togeth r with eve ’al eytokin ,The aim four tud was t
valuat a possible role of E’ in pathogenesis f pulmonary tub rculosis,
hen’ its 1:.1 ea s a mark r of a tivity of P1.rnI10n, 11 tuber ’11.1105i.