الفهرس 
Coronary heart diseasesOnly 14 pages are availabe for public view
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Abstract
This thesis was carried out to study the level of soluble
thrornbomodulin in coronary heart disease patient, and to shed light em
the possible role of’thrombornodulin in the pathogenesis ofCHD and also
to elucidate whether or not it can be considered as an independent risk
factor for H-ill.
I
It was performed on 70 subjects categorized as foil 0’2’:- -’
GrQup (I); included 4S patients complained of l.H.D. with ordinary
risk factors to ischaemia, which is also divided into 4 subgroups; _
Group (1 -A) with the main risk factors to ischaemia
was combined hypertension and D.M
Croup (l -B) with the main risk factor to Ischaemia
was hypertension
Group (l----C) with the main risk factor to ischaemia
wasD.M.
Group (I -D) with the main risk factor to ischaemia
W!lS hyperlipidaemia,
Group (2 ) 1 included 15 patient complained of 1.H.D. without
ordinary risk factors 10 ischaemia,
Group ( 3 ); include 10 apparently normal healthy subjects as a
control group.
All groups were subjected [0 full history taken, complete medical and
laboratory examination.
Venous blood Was sampled after 14-hol.lfs fasting for liver function
tests, kidney function tests, lipid profile, s. glucose, C.B.C., C.R.P., factor
vm activity and sTM level.
••. SUMMARY AND CONCWSJONS .••
Ou r results demonstrated the folJowing:
(A) - Resu Its in patients and control group
- There was highly significant decrease in T.M. level in patients groups
than control group.
-There was highly significant increase itl factor VIII activity in
patients groups than control group.
- The increase in creatinine level in cases groups was non significant,
-There WU~ non significant difference in TLC in all groups except
group (1.C) in which there was a highly significant increase in
TLC than control group.
-There is significant decrease in platelets count in patients with risk
factors only.
-There is highly signi licant increase in cholesterol and trigly~eridl!..~ and
LDL level in all groups & highly significant decrease in HDL-cholesterol
level in all groups than control group.
(B) - Correlation studies between thrembomodulln IIDd other
variables showed:
• Highly significant negative correlation between sTM
and Factor VIII in all groups
• Significant positive significant correlation between
sTM and TLC level and CRP level
• Non-significant correlation between sTM and age of
the patients.s.glucose, creatinine, cholesterol,
trigly<:eridesJ-IDL,LDL level and platelets count.