الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
In the present study, eleven pharmaceutical contaminants and 43 clinical isolates were collected and were shown to belong to ten different species as follows: one Klebsiella pneumonia (1.85%), six Kiebsiella aerogenes (11.11%), fifteen Escherichia coli (27.78%), thirteen Pseudomonas aeruginosa (24.07%), one Staphylococcus aureus (1.85%), eleven Staphylococcus saprophyticus (20.37%), four Staphylococcus epidermidis (7.4 1%), one Sarcina (1.85%), one Bacillus (1.85%) and one Candida (1.85%). For further characterization of the 53 bacterial isolates, their susceptibility to 22 commonly used antibiotics was determined by the modified disc diffusion method.
The antimicrobial activity of the sterile Chitosan solution alone has been determined against 20 different microorganisms, including isolates of different sources, having variable antibiotic resistance patterns and representing a wide range of different members of Gram-negative and Gram-positive bacteria, as well as yeasts, in addition to standard microorganisms.
The minimum inhibitory concentration (MIC) range of Chitosan against the Gram-negative bacteria was found to be 250-2000 ig/ml, while that against Gram-positive bacteria was much lower (15.625-125 ig/ml), indicating that Chitosan was more active against the latter than the former. In addition, the MIC values of Chitosan against both the Candida and the Aspergillus standards were much higher than those obtained against the Gram-positive bacteria. Furthermore, the Chitosan tested in our study.