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Abstract
In this work 50 cases of ovarian tumors were studied
Histopathologically
Immunohistochemically for C-erbB-2 expression
Flow cytometric study for DNA ploidy and S-phase fraction
from our study we conclude the following:
1- There is extensive expression of C-erbB-2 in epithelial ovarian tumors and it is overexpressed in ovarian carcinoma.
2- The expression of C-erbB-2 in borderline tumors tend to be like that of benign tumors, so these lesions are in fact benign and better classified as proliferative except in the minority they turn frankly malignant.
3- No significant correlation between of C-erbB-2 expression and the clinicopathological parameters including histologic type, tumor grade and tumor stage.
4- C-erbB-2 expression is of importance in patients with ovarian carcinoma who are under therapeutic planes.
5- No significant relation between C-erbB-2 expression and flowcytometric measurementa concerning DNA ploidy, S-phase fraction level and DNA index in ovarian tumors.
6- C-erbB-2 expression in germ cell tumors and sexcord-stromal tumors is indefinite and has no indication
7- Flowcytometric measurements concerning DNA ploidy, S-phase fraction level and DNA index in ovarian tumors are reflective of the biological state of the cell.
8- A fairly good correlation between DNA ploidy, S-phase fration and grade stage of ovarian carcinoma and so it is of value in predicting the prognosis.
9- A fairly good correlation between DNA ploidy and S-phase fraction.