الفهرس | Only 14 pages are availabe for public view |
Abstract BACK GROUND: Threatened abortion is the commonest complication in pregnancy, it is defined as vaginal bleeding with or without menstrual like cramps in the first 20 weeks of pregnancy. No history of passage of tissue or rupture of membrane is present and ultrasound demonstrates an intrauterine sac with fetal cardiac activity. OBJECTIVES: The predictive value of maternal hormonal serum level of inhibin A in cases of threatened abortion METHODS: Complete history taking, General clinical examination, Obstetric examination , Routine laboratory investigations, Ultrasound examination for detection of fetal viability and fetal parameters, Maternal blood samples were collected for determination of the quantitative measurement of inhibin A, Follow up of cases till reaching 20 weeks of gestational age. RESULTS: The results of the study were analysed statistically, and we found that There was a significant decrease in the levels of inhibin A in cases of threatened abortion but ongoing pregnancy (group B) compared with the control group. Much more significant lower levels of inhibin A were found in cases of threatened abortion and failing pregnancies (group A) compared with the cases of threatened abortion but ongoing pregnancies (group B). CONCLUSIONS: The cutoff value of inhibin A was measured, using the receiving operator curve (Roc curve), it was 268.9 pg/ml with a sensitivity of 82.5% and a specificity of 90.1% at 8 weeks, while it was 395.5 pg/ml with a sensitivity of 85.5% and a specificity of 90.5% at 10 weeks. |