الفهرس 
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Abstract
The aim of our work was to outline the clinico-pathological as well as immuno histochemical changes, in lesional a topic skin as well as non-lesional skin. In addition, these changes were compared with those of lichen simplex patients as well as normal control subjects. Lastly, evaluating the effect of topical treatment (pimecrolimus 1 % ointment) on these pathological and immuno histochemical changes.
Conclusion:
We can conclude that TRAIL is expressed in a topic skin and in lichen simplex as well as in normal subjects. This expression is significantly declined 3 weeks post-topical steroid or pimecrolimus. TRAIL expression can be correlated with the degree of the infiltrate being both increased together. These data support the anti-inflammatory role of TRAIL being increased in a trial to terminate the inflammatory process.
In the literature, the previous histopathologic alterations may be explained on the basis of keratinocyteee apoptosis, which precedes prognosis and other epidermal changes. In addition, TRAIL is thought to induce apoptosis in human keratinocytes. Taken together, TRAIL like False, is suggested to induce apoptosis in topic dermatitis. However, we can not exclude the possible other unknown functions of TRAIL in atopic dermatitis as well as in other inflammatory skin conditions.