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Abstract
The acute phase response is a constellation of host responses induced by infections, trauma inflammatory processes and some malignant diseases. Synthesis of several plasma proteins in the liver undergoes dramatic changes during this acute phase reaction. These proteins are called acute phase reactants.
C-reactive protein is the classical acute phase reactant. It is synthesized by hepatocytes and is normally present in plasma at levels < lmg/dl. Increased CRP production is a very early and sensitive response to most forms of microbial infections.
Fibrinogen is an acute phase protein whose rate of synthesis is markedly stimulated by inflammation or injury. The liver is the main site of fibrinogen synthesis. It circulates in the blood at approximately 300 mg/dl.
A large number of studies have reported on associations of human CHD and certain persistent bacterial and viral infection including H.pylori, C.pneumoniae and CMV.
Recent studies suggest that low- grade inflammation is present among patient at risk for future atherothrombotic disease.
Laboratory and pathological data support the idea that inflammation has a role in both the initiation and the progression of atherosclerosis and anti-inflammatory agents may have a role in the prevention of cardiovascular diseases.
The changes in the levels of acute phase proteins may provide an indirect measure of inflammation or injury to the arterial walls. It has been.