الفهرس 
Introduction and Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
This study begins a systemic examination of metabolic biochemistry of squamous cell carcinoma of the head and neck in order to characterize changes in enzymes and substrates occurring in this cancer that might eventually further our understanding of other biological parameters such as angiogenesis or tissue oxygenation or be correlated with biological behaviour or treatment outcome.
Enzyme activities will be assayed for malate dehydrogenise as a Krebs’ cycle enzyme indicating oxidative metabolism, lactate dehydrogenase as an indication of glycolytic metabolism and DPD activity will be determined in these tumours by using a new biochemical method. The quantitative data obtained from these enzymes will be compared to the data that obtained from adjacent stained sections for angiogenesis and tumour differentiation.
In conclusion, DPD activity is high in all solid tumours we examined but not in their counterparts, so our simple biochemical method is reasonable for DPD assay in freeze dried tumour tissue, and DPD can serve as a good marker for tumour progression as well as patient’s response to chemotherapy. We also suggest that tumour DPD can be used as a marker for DPD activity in general, and as a detrimental factor for patients with DPD deficiency who will receive 5-FU as chemotherapeutic drug and for prediction of clinical outcome. Meanwhile, MDH and LDH activities in the tumour tissue can serve as marker for malignant transformation and tumour progression. Tumour grade and depth as well as blood vessel density can be used as a biological profile for tumorgenicity.