الفهرس 
Background and Review of LiteratureOnly 14 pages are availabe for public view
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Abstract
Our study demonstrates defined benefits of aggressive lowering of mild to moderately elevated cholesterol levels in patients with coronary atherosclerosis. These benefits were mainly in the form of high threshold for, and better control of exertional angina, some reduction of treadmill evidence of ischemia, reduction of systolic blood pressure, an over all improvement of coronary reactivity of the conductance vessels in 7 (28%), some improvement in another 9 (30%) patients, halting the progression of the dysfunction in one patient and subsequently reduction of clinical coronary events.
The conclusions were:
1- The study hypothesis was difficult to prove because most of the segments neither dilated nor constricted, and the changes were at the limit of even the best QCA program.
2- Inclusion of the entire analyzable coronary artery and using of a limit of reproducibility for the QCA system used are essential for optimal assessment of segmental coronary VMR and its change following lipid-lowering.
3- Serial investigations that focus on selected segments showing the most visually detectable response to Ach are particularly vulnerable for erroneous conclusions.
4- Aggressive libid-lowering of mild to moderately elevated cholesterol levels in patients with mild CAD is definitely beneficial.
5- Endothelial dysfunction associated with hypercholesterolemia is mot all or non-rule but markedly heterogeneous with the presence of different degrees of dysfunction and partially reversible following lipid-lowering.
6- Lipid-lowering therapy was the only predictor of partial improvement in endothelial dysfunction. Therefore, earl detection of hypercholesterolemia and its correction may partially prevent the future development of advanced atherosclerotic lesions.