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Abstract It is noteworthy that the use of medicinal plants or their crude extract in the prevention and/or treatment of several acute and chronic diseases in various ethnic societies worldwide enjoyed a positive and welcomed come “Back to nature”. Our study was carried out on 234 male albino rats to evaluate the possible hepatoprotective activity of N.S. seeds and oil. The present work was divided into 2 experiments:The first experiment: Rats were subjected to receive N.S. oil at dose levels 0.4, 0.8 and 1.6 mi/kg b.wt. and N. S. seeds as fresh finely crushed at dose levels of 0.5 and 2 % daily for 3 and 6 weeks after that acute hepatotoxicity of rats was induced by receiving an oral dose of 10 ml/kg b.wt ethyl alcohol 50 % in water, 18 h. later, CC14 was i.p. injected at a dose 0.1 ml/kg b.wt.. The rats (144) were divided equally into 6 groups: 01: Basal diet + N.S. oil 0.4 ml / Kg b.wt. per os. G2: Basal diet + N.S. oil 0.8 ml / Kg b.wt. per os. 03: Basal diet + N.S. oil 1.6 ml / Kg b.wt. per os. 04: Basal diet + crushed N. S. seed 0.5 %. 05: Basal diet + crushed N.S. seed 2 %. 06: Basal diet + corn oil 2.5 % (Control group). After, 3 weeks of experiment 6 rats from each treated group as well as from the control were taken randomly for blood sampling and liver collection. Another 6 rats from each treated group as well as from the control were also taken randomly and were received the hepatotoxic agents which previously mentioned. 24 h after the later treatment of intoxication, blood sampling and liver collection were taken from all animals. |