الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Periodontitis is a chronic inflammatory disease characterized by the formation of a periodontal pocket with subsequent alveolar bone resorption, cementum and periodontal ligament tissue destruction. Different treatment modalities have been developed to arrest the periodontal disease and to rebuild the lost periodontal tissues, these modalities include non surgical and surgical techniques.
Healing following periodontal surgical flaps is considered a complex process which includes the coordination between various cell types under the control of different molecules called the growth factors. These growth factors also regulate cell interactions with the extracellular matrix molecules.
Among these growth factors, TGF-β1 is considered one of the most important molecules playing a major role in the early phases of healing. It is produced from platelets, neutrophils, macrphages, as well as from osteoblasts. TGF- attracts the inflammatory cells, stimulates fibroblast proliferation, extracellular matrix protein production, and angiogenesis. In addition, TGF- induces wound contraction.
GCF is considered a reflection of the ongoing cellular activities in the surrounding periodontal tissues. The constituents of GCF represent the components involved in tissue formation and remodeling as well as the products of tissue inflammation and destruction. Therefore, this study was conducted to detect the presence of TGF-β1 in GCF and the changes in its level following periodontal surgery which might be of value as a prognostic marker of wound healing activity and to differentiate between healing in different treatment modalities.