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Abstract
Coronary artery disease is one of the most prevalent diseases worldwide. In acute coronary syndrome, up regulation of angiogenic growth factors as a part of the compensatory mechanisms aims to restore the blood flow to the ischemic tissue. Among these angiogenic factors, are hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF). However, it is unknown whether or not; the level of these angiogenic growth factors is related to clinical outcome. We measured VEGF and HGF levels in 50 patients with a mean age of 59.3+5.78 years, as well as 10 age and sex matched healthy individuals as a control group. Then the patients were divided into two groups; group A with high VEGF level, and group B with high HGF level. Angiogenic evaluation of these patients was performed. Then the patients were followed for a period of six months for any ischemic manifestations, such as myocardial infarction, cerebral stroke and death. At the end of six months, all the patients performed stress test to detect residual ischemia. We found significant elevation of HGF and VEGF in patients with acute coronary syndrome as compared to the controls (p <0.001), and the total event rate in the group of patients with high HGF was significantly lower than that in the group of patients with high VEGF (p<0.001).
Conclusion: Angiogenic growth factors; VEGF and HGF could be independent predictors of patient prognosis in acute coronary syndrome, whereas, VEGF elevation is correlated to adverse outcome, HGF elevation was associated with a favorable prognosis.