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Abstract
Ozone is highly energetic activated form of oxygen, which has been used for human health since 1860.
Topical application of ozone has been used in management of gingivitis and periodontitis with no reliable data obtained regarding the direct effect of ozone on the periodontal tissues.
This stimulated the idea of the present work in studying the effect of using local ozonized water on the periodontal tissues of non-diabetic and diabetic rats in order to detect any pathological changes that may occur.
In this study, 240 male rats were used and the rats were divided into two main groups:
Group A: is the non-diabetic group and included 120 male rats. This group is further divided into four subgroups:
a) Control group (30 rats): this group did not receive any ozone application.
b) One ozone application group (30 rats): This group received one ozone application per week for different time periods namely 1, 3, and 6 months interval.
c) Two ozone applications group (30 rats): This group received two ozone applications per week for different time periods namely 1, 3, and 6 months interval.
d) Three ozone applications group (30 rats): This group received three ozone applications per week for different time periods namely 1, 3, and 6 months interval.
Each ten rats from the subgroups were sacrified after 1, 3, and 6 months.