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Abstract The aim of the present study was to investigate the effect(s) of prostaglandin (PGF2) and aspirin (pros— taglandin synthesis inhibitor) on spermatogenesis in albino rats. Mature male rats were divided into six equal groups each of which consisted of 6 rats. The first group (control) was injected with 0.1 ml saline under the tunica vaginalis of the left testis and injected subcutaneously with 0.2 ml 1% gum acasia and 0.1 ml olive oil. The second group was injected under the tunica vaginalis of the left testis with 50 Ug FGF2 in 0.1 ml saline. The third group was injected subcutaneously with 200 Ug testosterone in 0.1 in]. olive oil plus 50 Ug PGF2under the tunica vagi— nalis of the left testis. The fourth group was injected with 200 Ug testosterone subcutaneously. The Fifth group was injected subcutaneously with 30 Ug aspirin in 0.2 ml of 1% gum acasia. The sixth group was injected with 200 Ug testoterone plus 30 mg aspirin in gum acasia subcutaneously. Rats in all groups were injected daily for 15 days. Four hours after the last injection, LH content of the pituitaries and serum was determined. The gonads and accessory glands were weighed. The testes were processed for histological examination. The fructose content in the seminal vesioles and the sperm count in the cauda epididymidies were determined. |