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Abstract Recurrent pregnancy loss is a major obstetric problem. It is prevalent among 1-3% of fertile women and it is a disappointing problem in woman health. It is defined as 2 or more consecutive losses within less than 28 weeks of gestation. The risk of RPL increases with the number of previous pregnancy losses. The chance of having a normal pregnancy is 30% in a woman who had three recurrent pregnancy losses, 25% after 4 losses and 5% after 5 losses. RPL is affected by many factors including maternal age, number of previous miscarriages, familial and lifestyle factors. Also many medical problems can cause RPL. Among the most important causes of RPL are thrombophilias. Thrombophilias are disorders that predisposes to thrombosis. They can be hereditary or acquired. The former include genetic conditions and the latter are associated with a wide range of disease conditions. Some environmental factors are known to enhance thrombus formation, such as smoking, obesity, fractures, surgery, and immobility. |