الفهرس 
EpilepsyOnly 14 pages are availabe for public view
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Abstract
The biological actions of insulin are essential for the regulation and maintenance of glucose homeostasis. Insulin resistance is typically defined as a state of decreased sensitivity or responsiveness to the metabolic actions of insulin. Insulin resistance is also associated with obesity as well as hypertension, coronary artery disease, and dyslipidemias.
Valproate (VPA) is an extensively used broad spectrum antiepileptic drug. The duration of treatment may last for years which emphasize the importance of long term safety of the drug. It is established that VPA treatment is associated with weight gain. VPA treated patient were also observed to have serum triglyceride concentrations above the normal range than control subjects.
Thus the aim of this work was to evaluate the possible changes in insulin secretion, and metabolism during VPA treatment and the role of triglycerides in those changes as well as the role of insulin VPA related weight gain.
Our study was a case-control clinical trial which was carried out in the Neurology Clinic -Pediatric Hospital- Ain Shams University. Subjects were divided into two groups: Group 1: included 20 children and adolescents with epilepsy on VPA monotherapy. Group 2 included 10 non epileptic children and adolescents serving as controls.