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Abstract
The diagnosis of acute myocardial infarction (AMI) depends on evidence of myocyte necrosis provided by biochemical tests, clinical examination and electrocardiography (ECG) (The joint European society of cardiology / American college of cardiology, 2003).
The diagnosis or exclusion of AMI as early as possible after admission to the emergency unit is essential for good prognosis. New and expensive biochemical tests have been developed and are used for this purpose. Troponin (Tn), a regulatory protein of myocyte contractility specific to heart muscle was found to be a specific and sensitive marker of cardiac myocyte necrosis (Lang et al,2004).
Myoglobin , is another protein present in myocytes, has been found to peak early and hence useful in early diagnosis of AMI, though with a lower specificity (Panteghini et al, 1999).
In the proper clinical setting, CKMB is both sensitive and specific marker for early detection of AMI (Henry, 2001).