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Abstract In this study the role of some bacterial and parasitic agents in the causation of calf diarrhoea was studied. For this, 160 faecal samples were collected from diarrhoeic and apparently healthy calves as well as 160 soil samples for bacteriological and parasitological studie. The results could be summarized as follows: I. Bacteria: 1. The most common organism isolated from faeces of examined calves was E. coli (81.25%), moreover E. coli was the most common organism isolated both from diarrhoeic (85.7 1%) and apparently healthy calves (50%). The isolation rate of E. coli from 1—30, 3 1—60 and 6 1—90 days old calves was 86.25, 72.50 and 80%, respectively. The highest incidence of E. coli occurred in spring (87.5%). Isolation rate of E. coli from examined soil samples was 8 1.25% and its distribution across seasons was 85, 85, 80 and 75% for winter, spring, summer and autumn, respectively. 2. Salmonella species were isolated from calves at a percentage of 6.25%. Salmonella typhimurium, Sal. dublin and Sal. newport were isolated at a percentage of 3.13, 1.88 and 1.2.5%, respectively from examined calves. Salmonella was isolated from diarrhoeic and apparently healthy calves at a |