الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Sepsis—a state of systemic bacterial infection— runs through phases of very low blood pressure leading to dangerously reduced oxygen delivery to the tissues and frequently leads to multiorgan failure . Even today, this lifethreatening complication of infection is associated with significant morbidity and mortality in the intensive care unit,where it is the most common cause of mortality despite the recent advances achieved in intensive care treatment. Carbon monoxide (CO) and nitric oxide (NO) have also been implicated in various vascular alterations and directly participate in the cellular toxicity in sepsis.
To investigate the role of CO and NO in the pathogenesis of neonatal sepsis, plasma level of CO and urinary level of end products of NO( nitrites/nitrates) in 30 newborn infants with clinical evidences of neonatal sepsis plus positive blood cultures and positive C- reactive protein as well as 30 healthy newborn infants as a control group were assessed.
There was highly significant difference in plasma CO and urinary NO in sepsis group compared to control group (78.79± 20.52 vs. 32.16± 4.94 μmol L, P < 0.0001; 76.29± 20.91 vs. 30.99±5.18 μmol L, P < 0.0001, respectively).
There was no significant difference in plasma CO and urinary NO in PT sepsis group compared to FT sepsis group (78. 1±17.68 vs. 79.5±23.63 μmol L, P> 0.001; 74.73± 17.51 vs. 77.75± 24.39 μmol L, P>0.001, respectively).
There was no significant difference according to sex (74.27± 18.97 vs. 83.30± 21.64 μmol L, P > 0.05; 72.73± 17.40 vs. 79.85± 24.0 μmol L, P > 0.05, respectively).
There was no significant difference according to onset of sepsis (78.76± 21.91 vs. 78.89± 16.57 μmol L, P >0.05; 77.15± 20.57 vs. 78.76± 23.50 μmol L, P >0.05 respectively).
There was no significant differences according to the gram stain of the isolated organism or fungal infection (85.29±22.76 vs. 73.34±18.43 vs. 67.70± 9.50 μmol L, P >0.05; 81.36±22.2 vs. 73.86±21.02 vs. 63.83± 5.66 μmol L, P >0.05, respectively).
There was a high significant difference according to the inotropic support as there were significantly higher level of plasma CO and urinary NO in septic newborn infants who required inotropic support compared with those who did not require this support (102.88± 16.66 vs. 70.03± 13.69 μmol L, P <0.0001; 103.20± 17.30 vs. 66.50± 11.31 μmol L, P <0.0001, respectively).
There was a significantly positive correlation between plasma CO and urinary NO was observed.