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Abstract
One of the most toxic environmental pollutants known to man is dioxin that is generated as by-products from various combustion and chemical processes involving chlorine (Pinson, 2004). Dioxin elicits a broad spectrum of toxic and biochemical responses that include hepatotoxicity, cardiovascular toxicity, gastrointestinal toxicity, enzyme induction, tumor promotion and teratogenesis (NTP, 2006). Dioxin does not bind covalently to DNA, do not produce effects on the sister chromatid exchange frequency, and are negative in other genotoxicity tests (Kim et al., 2004).
The aim of this work was to assess the cardiovascular, hepato, intestinal, and genotoxic effects of dioxin and to evaluate the possible protective role of salicylamide against dioxin induced toxicities.
The present work was carried out on 200 adult malle albino rats, weighed 150 50 gm, which were divided into main four groups.