الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
The objective of the present work was to investigate
the pretreatment of mice with some xenobiotics on the sub¬sequent metabolism of kynurenine ”by the kynurenine metabo¬lizing enzymes, viz., kynurenine hydrolase and kynurenine aminotransferase. Somo of these xenobiotics are used as drugs, e.g. phenobarb.ltal, some dietary elements, e.g. in-dole, and some others are environmental pollutants, e.g. benzo(a)pyrene, 3-methylcholanthrene, aroclor 1254,/3~ naphthoflavone and pyrazole, and some others are used as antibiotics, e_.g. tetracycline, kanamycin and gentamicin. Moreover, most of these compounds are well known inducers of the mixed function monooxygenases in particular: aro¬clor 1254, 3-methylcholanthrene, benzo(a)pyrene, pheno-barbital, /^.-naphthoflavone, pyrazole, and indole. The liver and kidney enzymes were investigated since exposure to environmental pollutants and other xenobiotics may in¬duce differences in -;he susceptibility of these organs to chemical carcinogeneois possibly due to the differences in the metabolic response of these two organs to the pre-treatment with these xenobiotics. The effect of the pre-treatment with these chemicals on the liver:body weight ratio (%) was also studied.