الفهرس 
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Abstract
These experiments were carried out to study genetic effect of Ochratoxin A on mice. Ochratoxin A is toxic metabolite produced by fungus and has adverse effects on human and animal health. Also, in this study used Nigella sativa oil which considered one of the greatest healing herbs, to evaluate if it has protective effect against Ochratoxin A or not.
Experiments were done on different mice groups through two different ways of Ochratoxin A adminestration as following.
1. Acute treatment experiment.
In this experiment 40 mice were divided into five groups. The first three groups were used as control (without any treatment, NaHCO3 and Nigella sativa oil), the fourth group was administrated intraprotineally with 1.5 mg/Kg body weight Ochratoxin A, the fifth groups was administrated with the same dose of Ochratoxin A+160 mg/Kg body weight Nigella sativa oil. Half of the animals in each group were scarificed, and the samples were collected after 24 hours and the other half of animals were scarificed after 72 hours from administration. From this experiment the effects of Ochratoxin A and Ochratoxin A+Nigella sativa oil on mitotic activity and chromosomal abnormalities were determined.
2. Chronic treatment experiment.
In this experiment 48 mice were divided into five groups, the first three groups were used as control (without any