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Abstract The present study was carried out at the Hormone Laboratory, Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria Univerisity. The aim of this study was to investigate the effect of cadmium chloride, fenvalerate and/or their combination with or without p-carotene, vitamin E and/or their combination as antioxidants on growth performance, blood hematology, biochemical parameters, free radicals and semen characteristics of male rats. So this study included I three experiments. In the 1st one, cadmium chloride was used with or without (3- i carotene, vitamin E and/or their combination. In the 2 nd one, fenvalerate was used I finstead of CdCb while in the 3 rd experiment both CdCla and fenvalerate were used with tor without antioxidants. tThe results obtained can be summarized as follows: Experiment 1 Treatment with cadmium chloride caused: 1 - Significant (p<0.05) increase in the relative weights of kidney and spleen, and insignificant increase in liver weight. Testes and epididymes weights were significantly (P<0.05) decreased, and insignificant decrease in body weight. While treatment with cadmium chloride did not cause any change in the relative weights of brain, lung and heart. 2 - Significant (P<0.05) decline in Hb, TEC and PCV while, TLC increased. |