الفهرس | Only 14 pages are availabe for public view |
Abstract The aim of the present investigation was to demonstrate the effect of oral selenium administration on some hemodynamic and blood parameters in rats exposed to immobilization stress. 40 adult male albino rats, weighting 150-200 gram, were used in this work. The. rats were classified into two main groups: 1- Normal group. Which was classified into two equal subgroups: -Normal non-treated group. -Normal selenium-treated group. 11- Immobilized group. Which was classified into three equal subgroups: - Immobilized non-treated group. _ Immobilized selenium pre- & concomitant treated group. _ Immobilized selenium concomitant & post-treated group. In each of the previously mentioned groups, mean systolic blood pressure (MSBP), reactivity of aortic strip to l x l0-5M nor epinephrine, fasting serum sodium, potassium and lipids were performed The results showed that, oral sodium selenite administration (0.15 mg/ 100 g. B.W.) for 2 weeks, to normal rats resulted in insignificant changes in the mean systolic blood pressure, reactivity of aortic strip to l x l0-5M norepinephrine, fasting serum sodium, potassium and lipids when compared to the corresponding values in normal non-treated group. In immobilized non-treated group, there was significant increase in mean systolic blood pressure. |