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Abstract
Flow cytometry is a modality with ever increasing applications
in modern hematological, microbilogical and immunological fields. This
is due to rapidity of obtaining results, ease of use and insreasing power to
detect abnormal populations of cells. Recent advances in the availabilty
and reproducibility of monoclonal antibody reagents specific for a wide
range of of cell types coupled with lower costs for increasingly automated
flow cytometers and user data analysis capabilities have made flow
cytometry the method of choice for immunophenotyping in the clinical
laboratory(Dunphy 2004).
The use of flowcytometry in the clinical laboratory has grown
substantially in the past decade, this is attriutable to the development of
smaller, more user friendly, less expensive instruments and the
continuous increase in the types of monoclonal antibodies.In hematology
it can be used for Leukemia and Lymphoma phenotyping, identification
of prognostically important subgroups, detection of minimal residual
disease, multidrug resistance, in addition to diagnosis of paroxysmal
nocturnal haeoglobinuria and systemic mastocytosis.In immunology it
can be used for ctem cells enumeration, histocompatibility cross matching