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Abstract
Historically, high androgen levels have been linked with an increased risk for coronary artery disease (CAD). However, more recent data suggest that low androgen levels are associated with adverse cardiovascular risk factors, including an atherogenic lipid profile, obesity and insulin resistance.
In this study, we evaluated the relationship between serum testosterone levels and presence and degree of CAD in patients undergoing coronary angiography and in matched controls. We evaluated 60 male patients (mean age 54±4 years, range 47-63 years) referred for diagnostic coronary angiography because of symptoms suggestive of CAD, but without acute coronary syndromes or prior diagnosis of hypogonadism. Patients were matched with healthy volunteers. Out of 60 patients, 15 of them had one, 33 had two, and 12 had three vessel disease.